- A new study led by the CDC compared 5,000 healthcare workers in 25 states who had received either the Pfizer-BioNTech COVID Vaccine or Moderna Vaccine.
- After two doses, the Modern jab was 96.3% effective against symptomatic disease while the Pfizer shot was 88.9% effective.
- New research suggests modern vaccine may be more effective and produce higher levels of antibodies
- A health expert said both shots are still highly protective but Pfizer is a ‘big hammer’ while Moderna is a ‘hammer’.
Yet another study found that the modern COVID-19 vaccine may be more effective against the infection that Pfizer-BioNtech shot down.
Researchers led by the Centers for Disease Control and Prevention (CDC) compared the two vaccines in a real-world study of 5,000 healthcare workers in 25 states.
They found that Moderna Vaccine was 96 percent effective in preventing Covid symptomatic cases while the Pfizer jab was 89 percent effective.
The findings add to a growing body of evidence that while both vaccines are still highly protective, one may be higher than the other – and the interactions surrounding booster shots may have an impact.
Health experts have some theories about why Moderna’s vaccine dose is large and that the longer time period between two doses for Moderna vaccine gives more time to generate immune cells and antibodies.
A new study led by the CDC compared 5,000 healthcare workers in 25 states who had received either the Pfizer-BioNTech COVID Vaccine or Moderna Vaccine.
After two doses, the Modern jab was 96.3% effective against symptomatic disease, while the Pfizer shot was 88.9% effective—and the Modern jab was even more effective after a single dose.
Since vaccines were authorized by the U.S. Food and Drug Administration (FDA) in 2020, health officials and experts have said Americans should get whatever they want, because they’re all just as effective against the virus.
Both, which use new messenger RNA (mRNA) technology, were found to be about 95 percent effective in preventing disease in a clinical trial last year.
As of Thursday morning, 221.9 million people have received at least one dose of Pfizer and 150.2 million people have received at least one dose of Moderna, CDC data show.
However, several studies released over the past few months have shown that both are highly protective against COVID – one may be more protective than the other.
a canadian Study Looking at long-term care home residents in Ontario from August it was found that four weeks after dose 2, seniors receiving the Pfizer vaccine had 3.89 times fewer neutralizing antibodies than those receiving the Moderna jab.
Additionally, a Belgian Study, also published last month, an investigation of 1,600 workers in a major Belgian hospital system found that those who received the Moderna shot had antibody levels 2.65 times higher than those given the Pfizer vaccine.
What’s more, a CDC report released last week found that Moderna Vaccine was 93 percent effective against hospitalizations, compared with 88 percent for the Pfizer vaccine and 71 percent for the Johnson & Johnson jab.
The report also found that levels of antibodies in blood samples were highest among Moderna recipients in a separate group of healthy volunteers, compared to levels in Pfizer and J&J recipients.
The new study, published Wednesday in The New England Journal of Medicine, is the latest to report similar findings.
“Our basic assumption is that mRNA vaccines are working in a similar way, but then you start to see an isolation,” Dr. Natalie Dean, a biostatistician at Emory University in Atlanta, told The New York Times.
‘It’s not a huge difference, but at least it’s consistent.’
A CDC report last week observed that Moderna recipients had the highest levels of antibodies in blood samples in a separate group of healthy volunteers, compared to levels in Pfizer and J&J recipients.
More than 221.9 million people have received at least one dose of Pfizer and 150.2 million have received at least one dose of Moderna.
For the study, researchers looked at more than 5,000 healthcare workers in 25 states who were enrolled between December 28, 2020, and May 19, 2021.
Of the staff members, 1,482 had tested positive for COVID-19 with at least one symptom, while the remaining 3,449 had tested negative.
After partial vaccination and after full vaccination, that is, 14 days after the second dose, the effectiveness of the vaccine was evaluated.
The Pfizer vaccine was 77.6 percent effective against symptomatic infections after a single dose, while the Moderna vaccine was 88.8 percent effective.
After both doses, Pfizer’s shot was 88.9 percent effective while the Modern jab was 96.3 percent effective.
These rates were comparable regardless of age, race, gender or pre-existing conditions.
There are a few theories as to why there is a difference.
One theory is that a single dose of Moderna Vaccine is 100 micrograms (μg), compared to 30 micrograms for Pfizer.
The second is that because four weeks pass between two Moderna shots, compared to three weeks for two Pfizer shots, it can give antibodies more time to generate.
“At the end of the day, I think there are subtle but real differences between Moderna and Pfizer,” Dr. Jeffrey Wilson, an immunologist at the University of Virginia in Charlottesville, who was not involved in the study, told The Times.
‘In high-risk populations, this may be relevant. It would be good if people watch carefully. Pfizer is a big hammer, but Moderna is a sledgehammer.
If more studies continue to show similar findings, the conversation around booster shots could have an impact.
On Wednesday evening, a third dose of the Pfizer vaccine was approved by the FDA for people age 65 and older and those at high risk of serious illness.
Moderna has submitted data on its booster shot to the FDA and is awaiting officials…