- New data from Moderna found 88 successful cases of COVID-19 among people who were fully vaccinated between December 2020 and March 2021
- In comparison, there are 162 success cases among those vaccinated between July 2020 and December 2020 during clinical trials
- Moderna says these figures suggest that people who are fully vaccinated should get a booster shot six to eight months after their last dose.
- Preliminary data showed that a third dose after one month resulted in a 15-fold increase in neutralizing antibody levels.
Moderna Inc. says people who received its COVID-19 vaccine last year are almost twice as likely to have a successful infection than those who were recently vaccinated.
Breakthrough cases are when people contract the disease 14 days or more after receiving the last dose of the shot.
New data published on Wednesday found 88 successful cases of COVID-19 among Americans vaccinated from December 2020 to March 2021.
By comparison, there were 162 cases – 1.8 times more – among those vaccinated between July 2020 and December 2020.
The Cambridge, Massachusetts-based company reported 13 severe cases in the initial vaccination group, compared with six in the latter group.
What’s more, there were three COVID hospitalizations and two deaths in the vaccinated group last year, while there were no hospitalizations or deaths in the vaccinated group in winter 2020 and spring 2021.
Moderna says the data provides evidence for giving booster doses to fully vaccinated people.
New data from Moderna found 88 successful cases of COVID-19 among those who were fully vaccinated from December 2020 and March 2021, compared with 162 cases among those vaccinated between July 2020 and December 2020. Image: A vial of Moderna’s COVID-19 vaccine, April 7
Those who received their first dose last year were more likely to suffer severe breakthrough cases, be hospitalized or die compared to those who received the vaccine from winter 2020 to spring 2021 .
The data looked at people who participated in Moderna’s Phase 3 COVE study from last year and who received the vaccine after receiving emergency use authorization from the US Food and Drug Administration (FDA).
There were 162 successful COVID cases out of 14,746 people who received the vaccine between July 2020 and December 2020.
By comparison, 11,431 people who received the vaccine from December 2020 to March 2021 had 88 success cases.
Researchers say this means those who received their first dose 13 months earlier have 36 percent less protection than those who received their initial shot eight months ago.
More cases were observed in young adults for both groups.
Moderna says these figures suggest that people who are fully vaccinated should get a booster shot six to eight months after their last dose. Pictured: A health worker administers a shot of the Moderna COVID-19 vaccine in New York City, January 2021
In the 2020 vaccination group, there were 136 success cases for children aged 18 to 65 years and 26 cases in the 65 years and older group.
In the 2020-21 vaccination group, 68 cases were reported in the young adult group and 20 among senior citizens.
The initial vaccination group saw more severe cases of COVID-19 with 13 cases compared to six in the later group.
Seven serious success cases were reported among 18- to 65-year-olds who were vaccinated last year, compared with six in those aged 65 and older.
Moderna says this represents a 46 percent reduction in protection against severe cases in people who received the vaccine about a year ago.
In the recently vaccinated group, four cases were in young adults and two in older adults.
And while there were three success cases in the group that received their shots last year, resulting in hospitalizations and two deaths, this year none occurred in those receiving the shots.
Moderna CEO Stephane Bansel said, “The increased risk of breakthrough infection in study participants vaccinated last year compared to last year reflects the effect of weakened immunity and supports the need for boosters to maintain high levels of protection.” “ Press release.
‘We hope these findings will be helpful as health officials and regulators continue to assess strategies to end this pandemic.’
Moderna also shared data from its clinical trial looking at people who were given a booster shot six to eight months after their second dose.
They found that the level of neutralizing antibodies increased up to 15-fold after one month.
Levels, even in older adults – who normally produce a very weak immune response – were even higher than those recorded soon after the second dose.